WNK4
Entrez ID: 65266
Full name: WNK lysine deficient protein kinase 4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: WNK
Chromosomal location: 17q21.2
Substructure location: Gatekeeper: 254 A-loop: 320...341 G-loop: [N/A] αC-helix: [N/A]
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WNK4
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, S...
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K+ channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K+ secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).
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GO - Biological processes (BP):
chloride transport, distal tubule morphogenesis, intracellular signal transduction, ion homeostasis, ion transport, negative regulation of pancreatic juice secretion, negative regulation of sodium ion transport, positive regulation of ion transmembrane transporter activity, positive regulation of po...
chloride transport, distal tubule morphogenesis, intracellular signal transduction, ion homeostasis, ion transport, negative regulation of pancreatic juice secretion, negative regulation of sodium ion transport, positive regulation of ion transmembrane transporter activity, positive regulation of potassium ion import across plasma membrane, positive regulation of sodium ion transmembrane transporter activity, protein localization, protein phosphorylation, regulation of cellular process, renal sodium ion absorption
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GO - Molecular function (MF):
ATP binding, chloride channel inhibitor activity, potassium channel inhibitor activity, protein serine/threonine kinase activity...
ATP binding, chloride channel inhibitor activity, potassium channel inhibitor activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, bicellular tight junction, cytoplasm, membrane...
cytosol, bicellular tight junction, cytoplasm, membrane
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WNK lysine deficient protein kinase 4
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*NOTE: the Kaplan plots were collected from OncoLnc