PBK
Entrez ID: 55872
Full name: PDZ binding kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: TOPK
Chromosomal location: 8p21.1
Substructure location: Gatekeeper: 115 A-loop: 185...199, 200...211 G-loop: [N/A] αC-helix: 34...37
Please click HERE
for better display.
PBK
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage....
Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.
View more >>
GO - Biological processes (BP):
cellular response to UV, mitotic cell cycle, negative regulation of inflammatory response, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of stress-activated MAPK cascade...
cellular response to UV, mitotic cell cycle, negative regulation of inflammatory response, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of stress-activated MAPK cascade
View more >>
GO - Molecular function (MF):
ATP binding, MAP kinase kinase activity, protein serine/threonine kinase activity...
ATP binding, MAP kinase kinase activity, protein serine/threonine kinase activity
View more >>
GO - Cellular component (CC):
nucleus...
nucleus
View more >>
PDZ binding kinase
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for PBK in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc