MARK4
Entrez ID: 57787
Full name: microtubule affinity regulating kinase 4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: CAMKL: MARK
Chromosomal location: 19q13.32
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: 65...71 αC-helix: 92...94
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MARK4
Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in re...
Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942).
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GO - Biological processes (BP):
cell cycle, cell division, ciliary basal body-plasma membrane docking, cilium organization, intracellular signal transduction, microtubule bundle formation, microtubule cytoskeleton organization, nervous system development, positive regulation of cilium assembly, positive regulation of programmed ce...
cell cycle, cell division, ciliary basal body-plasma membrane docking, cilium organization, intracellular signal transduction, microtubule bundle formation, microtubule cytoskeleton organization, nervous system development, positive regulation of cilium assembly, positive regulation of programmed cell death, positive regulation of protein localization to centrosome, protein phosphorylation, regulation of centrosome cycle
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GO - Molecular function (MF):
ATP binding, gamma-tubulin binding, microtubule binding, protein serine/threonine kinase activity, tau protein binding, tau-protein kinase activity, ubiquitin binding...
ATP binding, gamma-tubulin binding, microtubule binding, protein serine/threonine kinase activity, tau protein binding, tau-protein kinase activity, ubiquitin binding
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GO - Cellular component (CC):
centrosome, ciliary basal body, gamma-tubulin complex, microtubule cytoskeleton, microtubule organizing center, cytosol, cytoplasm, dendrite, midbody, neuron projection...
centrosome, ciliary basal body, gamma-tubulin complex, microtubule cytoskeleton, microtubule organizing center, cytosol, cytoplasm, dendrite, midbody, neuron projection
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microtubule affinity regulating kinase 4
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*NOTE: the Kaplan plots were collected from OncoLnc