NEK1
Entrez ID: 4750
Full name: NIMA related kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: NEK: NEK1
Chromosomal location: 4q33
Substructure location: Gatekeeper: 80 A-loop: 145...168 G-loop: 7...20 αC-helix: 42...57
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NEK1
Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondria...
Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:20230784). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:20230784). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (PubMed:20230784). May be implicated in the control of meiosis (By similarity). Involved in cilium assembly (PubMed:21211617).
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GO - Biological processes (BP):
activation of protein kinase activity, cell cycle, cell division, cilium assembly, DNA damage response, detection of DNA damage, protein phosphorylation, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade...
activation of protein kinase activity, cell cycle, cell division, cilium assembly, DNA damage response, detection of DNA damage, protein phosphorylation, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
14-3-3 protein binding, ATP binding, kinase activity, metal ion binding, protein kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity...
14-3-3 protein binding, ATP binding, kinase activity, metal ion binding, protein kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity
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GO - Cellular component (CC):
centriolar satellite, centrosome, pericentriolar material, cytosol, nucleoplasm, nucleus, cytoplasm...
centriolar satellite, centrosome, pericentriolar material, cytosol, nucleoplasm, nucleus, cytoplasm
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NIMA related kinase 1
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Kaplan plot for NEK1 in
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*NOTE: the Kaplan plots were collected from OncoLnc