LMTK3
Entrez ID: 114783
Full name: lemur tyrosine kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Lmr
Chromosomal location: 19q13.33
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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LMTK3
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOX...
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity).
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GO - Biological processes (BP):
negative regulation of phosphatase activity...
negative regulation of phosphatase activity
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GO - Molecular function (MF):
ATP binding, metal ion binding, protein serine/threonine kinase activity...
ATP binding, metal ion binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
Golgi membrane, axon, dendrite, integral component of membrane...
Golgi membrane, axon, dendrite, integral component of membrane
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lemur tyrosine kinase 3
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Kaplan plot for LMTK3 in
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*NOTE: the Kaplan plots were collected from OncoLnc