SMG1
Entrez ID: 23049
Full name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: PIKK: SMG1
Chromosomal location: 16p12.3
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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SMG1
Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by r...
Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Also acts as a genotoxic stress-activated protein kinase that displays some functional overlap with ATM. Can phosphorylate p53/TP53 and is required for optimal p53/TP53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ.
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GO - Biological processes (BP):
DNA repair, mRNA export from nucleus, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, peptidyl-serine phosphorylation, phosphatidylinositol phosphorylation, protein autophosphorylation, regulation of response to DNA damage stimulus, regulation of telomere maintenance...
DNA repair, mRNA export from nucleus, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, peptidyl-serine phosphorylation, phosphatidylinositol phosphorylation, protein autophosphorylation, regulation of response to DNA damage stimulus, regulation of telomere maintenance
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GO - Molecular function (MF):
ATP binding, metal ion binding, protein kinase activity, protein serine/threonine kinase activity, RNA binding, telomeric DNA binding...
ATP binding, metal ion binding, protein kinase activity, protein serine/threonine kinase activity, RNA binding, telomeric DNA binding
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GO - Cellular component (CC):
cytosol, nucleoplasm, nucleus, cytoplasm...
cytosol, nucleoplasm, nucleus, cytoplasm
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SMG1 nonsense mediated mRNA decay associated PI3K related kinase
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Gatekeeper
A-loop
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αC-helix
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Kaplan plot for SMG1 in
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*NOTE: the Kaplan plots were collected from OncoLnc