ALPK1
Entrez ID: 80216
Full name: alpha kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: Alpha: Alpha-Unclassified
Chromosomal location: 4q25
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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ALPK1
Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (PubMed:28877472, PubMed:28222186, PubMed:30111836). Specifically rec...
Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (PubMed:28877472, PubMed:28222186, PubMed:30111836). Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria (PubMed:30111836). ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling (PubMed:30111836). May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A (PubMed:27169898). May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A (PubMed:15883161).
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GO - Biological processes (BP):
cytoplasmic pattern recognition receptor signaling pathway, innate immune response, positive regulation of I-kappaB kinase/NF-kappaB signaling...
cytoplasmic pattern recognition receptor signaling pathway, innate immune response, positive regulation of I-kappaB kinase/NF-kappaB signaling
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GO - Molecular function (MF):
ATP binding, monosaccharide binding, protein serine/threonine kinase activity...
ATP binding, monosaccharide binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol...
cytosol
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alpha kinase 1
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*NOTE: the Kaplan plots were collected from OncoLnc