TRPM7
Entrez ID: 54822
Full name: transient receptor potential cation channel subfamily M member 7
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: Alpha: ChaK
Chromosomal location: 15q21.2
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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TRPM7
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium infl...
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
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GO - Biological processes (BP):
actomyosin structure organization, calcium-dependent cell-matrix adhesion, calcium ion transmembrane transport, cellular magnesium ion homeostasis, necroptotic process, protein autophosphorylation, protein tetramerization...
actomyosin structure organization, calcium-dependent cell-matrix adhesion, calcium ion transmembrane transport, cellular magnesium ion homeostasis, necroptotic process, protein autophosphorylation, protein tetramerization
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GO - Molecular function (MF):
actin binding, ATP binding, calcium channel activity, metal ion binding, myosin binding, protein serine/threonine kinase activity...
actin binding, ATP binding, calcium channel activity, metal ion binding, myosin binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
plasma membrane, cell, integral component of membrane, ruffle...
plasma membrane, cell, integral component of membrane, ruffle
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transient receptor potential cation channel subfamily M member 7
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*NOTE: the Kaplan plots were collected from OncoLnc