PASK
Entrez ID: 23178
Full name: PAS domain containing serine/threonine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: CAMKL: PASK
Chromosomal location: 2q37.3
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: [N/A] αC-helix: 1051...1056
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PASK
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy h...
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.
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GO - Biological processes (BP):
energy homeostasis, intracellular signal transduction, negative regulation of glycogen biosynthetic process, positive regulation of translation, protein autophosphorylation, protein phosphorylation, regulation of glucagon secretion, regulation of respiratory gaseous exchange...
energy homeostasis, intracellular signal transduction, negative regulation of glycogen biosynthetic process, positive regulation of translation, protein autophosphorylation, protein phosphorylation, regulation of glucagon secretion, regulation of respiratory gaseous exchange
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GO - Molecular function (MF):
ATP binding, phosphatidylinositol binding, protein serine/threonine kinase activity...
ATP binding, phosphatidylinositol binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, nucleus, cytoplasm...
cytosol, nucleus, cytoplasm
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PAS domain containing serine/threonine kinase
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*NOTE: the Kaplan plots were collected from OncoLnc