CAMKK2
Entrez ID: 10645
Full name: calcium/calmodulin dependent protein kinase kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: CAMKK: CAMKK-Meta
Chromosomal location: 12q24.31
Substructure location: Gatekeeper: 267 A-loop: 329...352 G-loop: 170...177 αC-helix: 198...204
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CAMKK2
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of th...
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca2+ signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
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GO - Biological processes (BP):
calcium-mediated signaling, CAMKK-AMPK signaling cascade, cellular response to reactive oxygen species, MAPK cascade, positive regulation of autophagy of mitochondrion, positive regulation of protein phosphorylation, positive regulation of transcription, DNA-templated, protein autophosphorylation, p...
calcium-mediated signaling, CAMKK-AMPK signaling cascade, cellular response to reactive oxygen species, MAPK cascade, positive regulation of autophagy of mitochondrion, positive regulation of protein phosphorylation, positive regulation of transcription, DNA-templated, protein autophosphorylation, protein phosphorylation, regulation of protein kinase activity
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GO - Molecular function (MF):
ATP binding, calcium ion binding, calmodulin binding, calmodulin-dependent protein kinase activity, protein tyrosine kinase activity...
ATP binding, calcium ion binding, calmodulin binding, calmodulin-dependent protein kinase activity, protein tyrosine kinase activity
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GO - Cellular component (CC):
cytosol, nucleoplasm, neuron projection...
cytosol, nucleoplasm, neuron projection
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calcium/calmodulin dependent protein kinase kinase 2
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*NOTE: the Kaplan plots were collected from OncoLnc