TP53RK
Entrez ID: 112858
Full name: TP53 regulating kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: Bud32
Chromosomal location: 20q13.12
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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TP53RK
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety...
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806).
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GO - Biological processes (BP):
protein phosphorylation, regulation of signal transduction by p53 class mediator, tRNA processing, tRNA threonylcarbamoyladenosine metabolic process...
protein phosphorylation, regulation of signal transduction by p53 class mediator, tRNA processing, tRNA threonylcarbamoyladenosine metabolic process
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GO - Molecular function (MF):
ATP binding, hydrolase activity, p53 binding, protein serine/threonine kinase activity...
ATP binding, hydrolase activity, p53 binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
nucleoplasm, nucleus, cytoplasm, EKC/KEOPS complex...
nucleoplasm, nucleus, cytoplasm, EKC/KEOPS complex
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TP53 regulating kinase
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*NOTE: the Kaplan plots were collected from OncoLnc