MAP3K14
Entrez ID: 9020
Full name: mitogen-activated protein kinase kinase kinase 14
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE-Unique
Chromosomal location: 17q21.31
Substructure location: Gatekeeper: 469 A-loop: 533...561 G-loop: 406...412 αC-helix: 433...435
Please click HERE
for better display.
MAP3K14
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner....
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.
View more >>
GO - Biological processes (BP):
activation of protein kinase activity, cellular response to mechanical stimulus, defense response to virus, I-kappaB kinase/NF-kappaB signaling, immune response, NIK/NF-kappaB signaling, positive regulation of I-kappaB kinase/NF-kappaB signaling, regulation of mitotic cell cycle, signal transduction...
activation of protein kinase activity, cellular response to mechanical stimulus, defense response to virus, I-kappaB kinase/NF-kappaB signaling, immune response, NIK/NF-kappaB signaling, positive regulation of I-kappaB kinase/NF-kappaB signaling, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade, tumor necrosis factor-mediated signaling pathway
View more >>
GO - Molecular function (MF):
ATP binding, kinase activity, MAP kinase kinase kinase activity, NF-kappaB-inducing kinase activity, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, kinase activity, MAP kinase kinase kinase activity, NF-kappaB-inducing kinase activity, protein kinase activity, protein serine/threonine kinase activity
View more >>
GO - Cellular component (CC):
cytosol, fibrillar center, nucleoplasm, cytoplasm, intracellular membrane-bounded organelle...
cytosol, fibrillar center, nucleoplasm, cytoplasm, intracellular membrane-bounded organelle
View more >>
mitogen-activated protein kinase kinase kinase 14
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for MAP3K14 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc