PIK3R4
Entrez ID: 30849
Full name: phosphoinositide-3-kinase regulatory subunit 4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: VPS15
Chromosomal location: 3q22.1
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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PIK3R4
Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and e...
Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123).
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GO - Biological processes (BP):
autophagy of peroxisome, cellular response to glucose starvation, late endosome to vacuole transport, macroautophagy, phosphatidylinositol biosynthetic process, positive regulation of phosphatidylinositol 3-kinase activity, protein phosphorylation, protein targeting to vacuole, receptor catabolic pr...
autophagy of peroxisome, cellular response to glucose starvation, late endosome to vacuole transport, macroautophagy, phosphatidylinositol biosynthetic process, positive regulation of phosphatidylinositol 3-kinase activity, protein phosphorylation, protein targeting to vacuole, receptor catabolic process, regulation of cytokinesis, toll-like receptor 9 signaling pathway
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GO - Molecular function (MF):
ATP binding, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
axoneme, microtubule cytoskeleton, cytosol, late endosome, autophagosome, intracellular membrane-bounded organelle, membrane, nucleus-vacuole junction, phagocytic vesicle membrane, phosphatidylinositol 3-kinase complex, class III, phosphatidylinositol 3-kinase complex, class III, type I, phosphatidy...
axoneme, microtubule cytoskeleton, cytosol, late endosome, autophagosome, intracellular membrane-bounded organelle, membrane, nucleus-vacuole junction, phagocytic vesicle membrane, phosphatidylinositol 3-kinase complex, class III, phosphatidylinositol 3-kinase complex, class III, type I, phosphatidylinositol 3-kinase complex, class III, type II
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phosphoinositide-3-kinase regulatory subunit 4
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A-loop
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G-loop
αC-helix
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Kaplan plot for PIK3R4 in
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*NOTE: the Kaplan plots were collected from OncoLnc