PKMYT1
Entrez ID: 9088
Full name: protein kinase, membrane associated tyrosine/threonine 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: WEE: WEE1
Chromosomal location: 16p13.3
Substructure location: Gatekeeper: 187 A-loop: 250...272 G-loop: 117...124 αC-helix: 148...164
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PKMYT1
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 o...
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
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GO - Biological processes (BP):
G2/M transition of mitotic cell cycle, mitotic cell cycle, negative regulation of phosphatase activity, regulation of cyclin-dependent protein serine/threonine kinase activity, regulation of mitotic nuclear division...
G2/M transition of mitotic cell cycle, mitotic cell cycle, negative regulation of phosphatase activity, regulation of cyclin-dependent protein serine/threonine kinase activity, regulation of mitotic nuclear division
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GO - Molecular function (MF):
ATP binding, kinase activity, metal ion binding, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, kinase activity, metal ion binding, protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, Golgi apparatus, Golgi membrane, nucleolus, nucleoplasm, nucleus, membrane...
cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, Golgi apparatus, Golgi membrane, nucleolus, nucleoplasm, nucleus, membrane
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protein kinase, membrane associated tyrosine/threonine 1
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*NOTE: the Kaplan plots were collected from OncoLnc