VRK1
Entrez ID: 7443
Full name: VRK serine/threonine kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CK1: VRK
Chromosomal location: 14q32.2
Substructure location: Gatekeeper: 131 A-loop: 196...226 G-loop: [N/A] αC-helix: 78...90
Please click HERE
for better display.
VRK1
Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the inter...
Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.
View more >>
GO - Biological processes (BP):
cell division, Golgi disassembly, histone H3-S10 phosphorylation, histone H3-T3 phosphorylation, mitotic nuclear envelope disassembly, mitotic nuclear envelope reassembly, peptidyl-serine phosphorylation, protein autophosphorylation, protein phosphorylation, Wnt signaling pathway...
cell division, Golgi disassembly, histone H3-S10 phosphorylation, histone H3-T3 phosphorylation, mitotic nuclear envelope disassembly, mitotic nuclear envelope reassembly, peptidyl-serine phosphorylation, protein autophosphorylation, protein phosphorylation, Wnt signaling pathway
View more >>
GO - Molecular function (MF):
ATP binding, histone kinase activity (H3-S10 specific), histone kinase activity (H3-T3 specific), nucleosomal histone binding, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity...
ATP binding, histone kinase activity (H3-S10 specific), histone kinase activity (H3-T3 specific), nucleosomal histone binding, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity
View more >>
GO - Cellular component (CC):
spindle, cytosol, Golgi stack, nucleolus, nucleoplasm, nucleus, cytoplasm...
spindle, cytosol, Golgi stack, nucleolus, nucleoplasm, nucleus, cytoplasm
View more >>
VRK serine/threonine kinase 1
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for VRK1 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc