EIF2AK1
Entrez ID: 27102
Full name: eukaryotic translation initiation factor 2 alpha kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: PEK: HRI
Chromosomal location: 7p22.1
Substructure location: Gatekeeper: 392 A-loop: 460...469, 484...495 G-loop: [N/A] αC-helix: [N/A]
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EIF2AK1
Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Bind...
Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. Thus plays an essential protective role for RBC survival in anemias of iron deficiency. Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes. May also contain ER stress during acute heme-deficient conditions (By similarity).
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GO - Biological processes (BP):
acute inflammatory response, iron ion homeostasis, macrophage differentiation, negative regulation of cell population proliferation, negative regulation of hemoglobin biosynthetic process, negative regulation of translational initiation by iron, phagocytosis, protein autophosphorylation, protoporphy...
acute inflammatory response, iron ion homeostasis, macrophage differentiation, negative regulation of cell population proliferation, negative regulation of hemoglobin biosynthetic process, negative regulation of translational initiation by iron, phagocytosis, protein autophosphorylation, protoporphyrinogen IX metabolic process, regulation of eIF2 alpha phosphorylation by heme, response to iron ion starvation
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GO - Molecular function (MF):
ATP binding, eukaryotic translation initiation factor 2alpha kinase activity, heme binding, protein homodimerization activity, protein kinase activity...
ATP binding, eukaryotic translation initiation factor 2alpha kinase activity, heme binding, protein homodimerization activity, protein kinase activity
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GO - Cellular component (CC):
cytoplasm...
cytoplasm
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eukaryotic translation initiation factor 2 alpha kinase 1
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Kaplan plot for EIF2AK1 in
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*NOTE: the Kaplan plots were collected from OncoLnc