RIOK1
Entrez ID: 83732
Full name: RIO kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: RIO: RIO1
Chromosomal location: 6p24.3
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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RIOK1
Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate ...
Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (PubMed:21081503).
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GO - Biological processes (BP):
maturation of SSU-rRNA, positive regulation of rRNA processing, ribosomal small subunit biogenesis...
maturation of SSU-rRNA, positive regulation of rRNA processing, ribosomal small subunit biogenesis
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GO - Molecular function (MF):
ATP binding, hydrolase activity, metal ion binding, protein serine/threonine kinase activity...
ATP binding, hydrolase activity, metal ion binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, nucleoplasm, methyltransferase complex, preribosome, small subunit precursor...
cytosol, nucleoplasm, methyltransferase complex, preribosome, small subunit precursor
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RIO kinase 1
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Gatekeeper
A-loop
G-loop
αC-helix
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A-loop
G-loop
αC-helix
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Kaplan plot for RIOK1 in
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*NOTE: the Kaplan plots were collected from OncoLnc