RIOK2
Entrez ID: 55781
Full name: RIO kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: RIO: RIO2
Chromosomal location: 5q15
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
Please click HERE
for better display.
RIOK2
Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late p...
Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710).
View more >>
GO - Biological processes (BP):
cell cycle, maturation of SSU-rRNA, positive regulation of ribosomal small subunit export from nucleus, positive regulation of rRNA processing, protein autophosphorylation, regulation of mitotic metaphase/anaphase transition, ribosomal small subunit biogenesis...
cell cycle, maturation of SSU-rRNA, positive regulation of ribosomal small subunit export from nucleus, positive regulation of rRNA processing, protein autophosphorylation, regulation of mitotic metaphase/anaphase transition, ribosomal small subunit biogenesis
View more >>
GO - Molecular function (MF):
ATP binding, metal ion binding, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, metal ion binding, protein kinase activity, protein serine/threonine kinase activity
View more >>
GO - Cellular component (CC):
cytosol, nucleoplasm, nucleus, cytoplasm, preribosome, small subunit precursor...
cytosol, nucleoplasm, nucleus, cytoplasm, preribosome, small subunit precursor
View more >>
RIO kinase 2
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for RIOK2 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc