KinaseMD - TRPM6

TRPM6 Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region.... Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region. View more >>

GO - Biological processes (BP): calcium ion transmembrane transport, protein tetramerization, response to toxic substance... calcium ion transmembrane transport, protein tetramerization, response to toxic substance View more >>

GO - Molecular function (MF): ATP binding, calcium channel activity, metal ion binding, protein serine/threonine kinase activity... ATP binding, calcium channel activity, metal ion binding, protein serine/threonine kinase activity View more >>

GO - Cellular component (CC): apical plasma membrane, brush border membrane, plasma membrane, integral component of membrane... apical plasma membrane, brush border membrane, plasma membrane, integral component of membrane View more >>

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transient receptor potential cation channel subfamily M member 6

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Dataset	Cancer	Sample	AAchange	Mutation

Substructure	Dataset	Cancer	Sample	AAchange	Mutation

Substrate	Psite	Mutation	Mutation location	Influence	Score1	Score2	Psite evidence	Mutation evidence

Dataset	Cell ID	Cell name	Cancer	Drug	IC50(uM)

Kinase	Drug	Cancer code	Cancer type	AVG_IC50(uM)(mutated)	AVG_IC50(uM)(Non-mutated)	Details

Kaplan plot for TRPM6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

KinaseMD: Kinase mutations and drug responses

TRPM6

Entrez ID: 140803

Full name: transient receptor potential cation channel subfamily M member 6

External links: HGNC UniprotKB Ensembl RefSeq COSMIC

Family: Atypical: Alpha: ChaK

Chromosomal location: 9q21.13

Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:

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Kaplan plot for TRPM6 in