STRADB
Entrez ID: 55437
Full name: STE20 related adaptor beta
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: STLK
Chromosomal location: 2q33.1
Substructure location: Gatekeeper: 136 A-loop: [N/A] G-loop: [N/A] αC-helix: [N/A]
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STRADB
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (B...
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).
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GO - Biological processes (BP):
activation of protein kinase activity, cell cycle arrest, cell morphogenesis, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, protein export from nucleus, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated protein kin...
activation of protein kinase activity, cell cycle arrest, cell morphogenesis, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, protein export from nucleus, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, protein serine/threonine kinase activity...
ATP binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, nucleus, aggresome, cytoplasm...
cytosol, nucleus, aggresome, cytoplasm
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STE20 related adaptor beta
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A-loop
G-loop
αC-helix
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G-loop
αC-helix
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*NOTE: the Kaplan plots were collected from OncoLnc