SIK2
Entrez ID: 23235
Full name: salt inducible kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: CAMKL: QIK
Chromosomal location: 11q23.1
Substructure location: Gatekeeper: 96 A-loop: 159...181 G-loop: [N/A] αC-helix: [N/A]
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SIK2
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators....
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
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GO - Biological processes (BP):
intracellular signal transduction, protein autophosphorylation, protein phosphorylation, regulation of insulin receptor signaling pathway...
intracellular signal transduction, protein autophosphorylation, protein phosphorylation, regulation of insulin receptor signaling pathway
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GO - Molecular function (MF):
ATP binding, magnesium ion binding, protein serine/threonine kinase activity...
ATP binding, magnesium ion binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
nucleus, cytoplasm...
nucleus, cytoplasm
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salt inducible kinase 2
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Kaplan plot for SIK2 in
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*NOTE: the Kaplan plots were collected from OncoLnc