KinaseMD - SRMS

SRMS Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues (PubMed:23822091). Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues (PubMed:29496907). Phosphorylation of KHDRBS1 is EGF-dependent (PubMed:29496907).... Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues (PubMed:23822091). Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues (PubMed:29496907). Phosphorylation of KHDRBS1 is EGF-dependent (PubMed:29496907). View more >>

GO - Biological processes (BP): cell differentiation, cell migration, negative regulation of signal transduction, peptidyl-tyrosine autophosphorylation, peptidyl-tyrosine phosphorylation, regulation of cell population proliferation, transmembrane receptor protein tyrosine kinase signaling pathway... cell differentiation, cell migration, negative regulation of signal transduction, peptidyl-tyrosine autophosphorylation, peptidyl-tyrosine phosphorylation, regulation of cell population proliferation, transmembrane receptor protein tyrosine kinase signaling pathway View more >>

GO - Molecular function (MF): ATP binding, non-membrane spanning protein tyrosine kinase activity, protein tyrosine kinase activity, signaling receptor binding... ATP binding, non-membrane spanning protein tyrosine kinase activity, protein tyrosine kinase activity, signaling receptor binding View more >>

GO - Cellular component (CC): cytosol, extrinsic component of cytoplasmic side of plasma membrane, cytoplasm... cytosol, extrinsic component of cytoplasmic side of plasma membrane, cytoplasm View more >>

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src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites

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Dataset	Cancer	Sample	AAchange	Mutation

Substructure	Dataset	Cancer	Sample	AAchange	Mutation

Substrate	Psite	Mutation	Mutation location	Influence	Score1	Score2	Psite evidence	Mutation evidence

Dataset	Cell ID	Cell name	Cancer	Drug	IC50(uM)

Kinase	Drug	Cancer code	Cancer type	AVG_IC50(uM)(mutated)	AVG_IC50(uM)(Non-mutated)	Details

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*NOTE: the Kaplan plots were collected from OncoLnc

KinaseMD: Kinase mutations and drug responses

SRMS

Entrez ID: 6725

Full name: src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites

External links: HGNC UniprotKB Ensembl RefSeq COSMIC

Family: TK: Src: SRM

Chromosomal location: 20q13.33

Substructure location: Gatekeeper: 302 A-loop: 367...381, 383...391 G-loop: [N/A] αC-helix: [N/A]

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Kaplan plot for SRMS in