HIPK3
Entrez ID: 10114
Full name: homeodomain interacting protein kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: DYRK: HIPK
Chromosomal location: 11p13
Substructure location: Gatekeeper: 275 A-loop: 343...364 G-loop: [N/A] αC-helix: [N/A]
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HIPK3
Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional c...
Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
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GO - Biological processes (BP):
apoptotic process, mRNA transcription, negative regulation of apoptotic process, negative regulation of JUN kinase activity, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, protein phosphorylation...
apoptotic process, mRNA transcription, negative regulation of apoptotic process, negative regulation of JUN kinase activity, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, protein phosphorylation
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GO - Molecular function (MF):
ATP binding, protein kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity...
ATP binding, protein kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity
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GO - Cellular component (CC):
cytosol, nuclear body, nucleus, PML body, cytoplasm...
cytosol, nuclear body, nucleus, PML body, cytoplasm
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homeodomain interacting protein kinase 3
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Kaplan plot for HIPK3 in
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*NOTE: the Kaplan plots were collected from OncoLnc