WNK1
Entrez ID: 65125
Full name: WNK lysine deficient protein kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: WNK
Chromosomal location: 12p13.33
Substructure location: Gatekeeper: 301 A-loop: 367...388 G-loop: [N/A] αC-helix: 266...273
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WNK1
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, ...
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).
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GO - Biological processes (BP):
cellular response to chemokine, chemokine (C-C motif) ligand 21 signaling pathway, intracellular signal transduction, ion homeostasis, ion transport, lymphocyte migration into lymph node, negative regulation of cell-cell adhesion mediated by integrin, negative regulation of GTPase activity, negative...
cellular response to chemokine, chemokine (C-C motif) ligand 21 signaling pathway, intracellular signal transduction, ion homeostasis, ion transport, lymphocyte migration into lymph node, negative regulation of cell-cell adhesion mediated by integrin, negative regulation of GTPase activity, negative regulation of heterotypic cell-cell adhesion, negative regulation of leukocyte cell-cell adhesion, negative regulation of phosphatase activity, negative regulation of sodium ion transport, neuron development, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of canonical Wnt signaling pathway, positive regulation of ion transmembrane transporter activity, positive regulation of potassium ion import across plasma membrane, positive regulation of sodium ion transmembrane transporter activity, positive regulation of T cell chemotaxis, protein phosphorylation, regulation of cation transmembrane transport, regulation of cellular process, regulation of sodium ion transport, signal transduction by trans-phosphorylation, T cell receptor signaling pathway
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GO - Molecular function (MF):
ATP binding, chloride channel inhibitor activity, phosphatase binding, potassium channel inhibitor activity, protein kinase activator activity, protein kinase activity, protein kinase binding, protein kinase inhibitor activity, protein serine/threonine kinase activity...
ATP binding, chloride channel inhibitor activity, phosphatase binding, potassium channel inhibitor activity, protein kinase activator activity, protein kinase activity, protein kinase binding, protein kinase inhibitor activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, cytoplasm, membrane...
cytosol, cytoplasm, membrane
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WNK lysine deficient protein kinase 1
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Kaplan plot for WNK1 in
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*NOTE: the Kaplan plots were collected from OncoLnc