PLK3
Entrez ID: 1263
Full name: polo like kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: PLK: PLK2
Chromosomal location: 1p34.1
Substructure location: Gatekeeper: 139 A-loop: 202...225 G-loop: 67...77 αC-helix: 95...98
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PLK3
Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC2...
Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.
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GO - Biological processes (BP):
apoptotic process, cellular response to DNA damage stimulus, cytoplasmic microtubule organization, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, endomitotic cell cycle, G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, Golg...
apoptotic process, cellular response to DNA damage stimulus, cytoplasmic microtubule organization, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, endomitotic cell cycle, G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, Golgi disassembly, mitotic cell cycle, mitotic cell cycle checkpoint, mitotic G1/S transition checkpoint, negative regulation of apoptotic process, negative regulation of transcription by RNA polymerase II, positive regulation of chaperone-mediated autophagy, positive regulation of intracellular protein transport, positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia, protein kinase B signaling, protein phosphorylation, regulation of cell division, regulation of cytokinesis, regulation of signal transduction by p53 class mediator, response to osmotic stress, response to radiation, response to reactive oxygen species
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GO - Molecular function (MF):
ATP binding, p53 binding, protein serine/threonine kinase activity...
ATP binding, p53 binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
centrosome, spindle pole, Golgi stack, nucleolus, nucleoplasm, nucleus, cytoplasm, dendrite, neuronal cell body...
centrosome, spindle pole, Golgi stack, nucleolus, nucleoplasm, nucleus, cytoplasm, dendrite, neuronal cell body
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polo like kinase 3
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Kaplan plot for PLK3 in
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*NOTE: the Kaplan plots were collected from OncoLnc