CLK4
Entrez ID: 57396
Full name: CDC like kinase 4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: CLK
Chromosomal location: 5q35.3
Substructure location: Gatekeeper: 239 A-loop: 322...342 G-loop: [N/A] αC-helix: [N/A]
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CLK4
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylate...
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
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GO - Biological processes (BP):
protein autophosphorylation, regulation of RNA splicing...
protein autophosphorylation, regulation of RNA splicing
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GO - Molecular function (MF):
ATP binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity...
ATP binding, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity
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GO - Cellular component (CC):
nucleus...
nucleus
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CDC like kinase 4
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αC-helix
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Kaplan plot for CLK4 in
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*NOTE: the Kaplan plots were collected from OncoLnc