MKNK2
Entrez ID: 2872
Full name: MAPK interacting serine/threonine kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: MAPKAPK: MNK
Chromosomal location: 19p13.3
Substructure location: Gatekeeper: 159 A-loop: 225...255 G-loop: [N/A] αC-helix: 123...135
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MKNK2
Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap...
Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As2O3-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.
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GO - Biological processes (BP):
cell surface receptor signaling pathway, cellular response to arsenic-containing substance, extrinsic apoptotic signaling pathway in absence of ligand, hemopoiesis, intracellular signal transduction, peptidyl-serine phosphorylation, protein autophosphorylation, protein phosphorylation, regulation of...
cell surface receptor signaling pathway, cellular response to arsenic-containing substance, extrinsic apoptotic signaling pathway in absence of ligand, hemopoiesis, intracellular signal transduction, peptidyl-serine phosphorylation, protein autophosphorylation, protein phosphorylation, regulation of translation
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GO - Molecular function (MF):
ATP binding, calcium-dependent protein serine/threonine kinase activity, calmodulin binding, metal ion binding, protein serine/threonine kinase activity...
ATP binding, calcium-dependent protein serine/threonine kinase activity, calmodulin binding, metal ion binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
nuclear body, nucleoplasm, nucleus, PML body, cytoplasm...
nuclear body, nucleoplasm, nucleus, PML body, cytoplasm
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MAPK interacting serine/threonine kinase 2
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*NOTE: the Kaplan plots were collected from OncoLnc