NEK6
Entrez ID: 10783
Full name: NIMA related kinase 6
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: NEK: NEK6
Chromosomal location: 9q33.3
Substructure location: Gatekeeper: 122 A-loop: 189...212 G-loop: [N/A] αC-helix: [N/A]
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NEK6
Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:14563848). Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis (PubMed:19414596). Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TR...
Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:14563848). Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis (PubMed:19414596). Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3 (PubMed:12054534, PubMed:20873783). Phosphorylates KIF11 to promote mitotic spindle formation (PubMed:19001501). Involved in G2/M phase cell cycle arrest induced by DNA damage (PubMed:18728393). Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (PubMed:21099361).
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GO - Biological processes (BP):
apoptotic process, cell division, chromosome segregation, mitotic nuclear envelope disassembly, peptidyl-serine phosphorylation, positive regulation of I-kappaB kinase/NF-kappaB signaling, protein autophosphorylation, protein phosphorylation, regulation of cellular senescence, regulation of mitotic ...
apoptotic process, cell division, chromosome segregation, mitotic nuclear envelope disassembly, peptidyl-serine phosphorylation, positive regulation of I-kappaB kinase/NF-kappaB signaling, protein autophosphorylation, protein phosphorylation, regulation of cellular senescence, regulation of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, spindle assembly
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GO - Molecular function (MF):
activating transcription factor binding, ATP binding, kinesin binding, magnesium ion binding, protein kinase binding, protein serine/threonine kinase activity, transcription corepressor binding, ubiquitin protein ligase binding...
activating transcription factor binding, ATP binding, kinesin binding, magnesium ion binding, protein kinase binding, protein serine/threonine kinase activity, transcription corepressor binding, ubiquitin protein ligase binding
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GO - Cellular component (CC):
centriolar satellite, microtubule, spindle pole, cytosol, nuclear speck, nucleoplasm, nucleus, cytoplasm, intracellular membrane-bounded organelle, protein-containing complex...
centriolar satellite, microtubule, spindle pole, cytosol, nuclear speck, nucleoplasm, nucleus, cytoplasm, intracellular membrane-bounded organelle, protein-containing complex
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NIMA related kinase 6
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*NOTE: the Kaplan plots were collected from OncoLnc