PAK6
Entrez ID: 56924
Full name: p21 (RAC1) activated kinase 6
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: PAKB
Chromosomal location: 15q15.1
Substructure location: Gatekeeper: 481 A-loop: 543...566 G-loop: 414...421 αC-helix: 446...448
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PAK6
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ES...
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.
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GO - Biological processes (BP):
activation of protein kinase activity, apoptotic process, cytoskeleton organization, learning, locomotory behavior, memory, neuron projection arborization, neuron projection extension, regulation of mitotic cell cycle, regulation of transcription, DNA-templated, signal transduction by protein phosph...
activation of protein kinase activity, apoptotic process, cytoskeleton organization, learning, locomotory behavior, memory, neuron projection arborization, neuron projection extension, regulation of mitotic cell cycle, regulation of transcription, DNA-templated, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, cadherin binding, protein serine/threonine kinase activity...
ATP binding, cadherin binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
fibrillar center, nucleoplasm, cell junction, cytoplasm...
fibrillar center, nucleoplasm, cell junction, cytoplasm
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p21 (RAC1) activated kinase 6
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Kaplan plot for PAK6 in
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*NOTE: the Kaplan plots were collected from OncoLnc