STK36
Entrez ID: 27148
Full name: serine/threonine kinase 36
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: ULK: Fused
Chromosomal location: 2q35
Substructure location: Gatekeeper: 80 A-loop: 142...165 G-loop: [N/A] αC-helix: [N/A]
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STK36
Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their ...
Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (By similarity). Essential for construction of the central pair apparatus of motile cilia.
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GO - Biological processes (BP):
brain development, cilium assembly, epithelial cilium movement involved in extracellular fluid movement, positive regulation of hh target transcription factor activity, positive regulation of smoothened signaling pathway, post-embryonic development, protein phosphorylation, regulation of DNA-binding...
brain development, cilium assembly, epithelial cilium movement involved in extracellular fluid movement, positive regulation of hh target transcription factor activity, positive regulation of smoothened signaling pathway, post-embryonic development, protein phosphorylation, regulation of DNA-binding transcription factor activity
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GO - Molecular function (MF):
ATP binding, metal ion binding, protein serine/threonine kinase activity, transcription factor binding...
ATP binding, metal ion binding, protein serine/threonine kinase activity, transcription factor binding
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GO - Cellular component (CC):
cytosol, extracellular region, nucleus, cytoplasm...
cytosol, extracellular region, nucleus, cytoplasm
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serine/threonine kinase 36
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*NOTE: the Kaplan plots were collected from OncoLnc