MAP3K20
Entrez ID: 51776
Full name: mitogen-activated protein kinase kinase kinase 20
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: MLK: MLK
Chromosomal location: 2q31.1
Substructure location: Gatekeeper: 82 A-loop: 150...171 G-loop: 19...31 αC-helix: 22...25
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MAP3K20
Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycl...
Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636).
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GO - Biological processes (BP):
activation of JUN kinase activity, activation of MAPKK activity, cell cycle arrest, cell death, cell differentiation, cellular response to gamma radiation, cytoskeleton organization, DNA damage checkpoint, embryonic digit morphogenesis, limb development, mitotic cell cycle checkpoint, positive regul...
activation of JUN kinase activity, activation of MAPKK activity, cell cycle arrest, cell death, cell differentiation, cellular response to gamma radiation, cytoskeleton organization, DNA damage checkpoint, embryonic digit morphogenesis, limb development, mitotic cell cycle checkpoint, positive regulation of apoptotic process, protein phosphorylation, stress-activated MAPK cascade
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GO - Molecular function (MF):
ATP binding, magnesium ion binding, MAP kinase kinase kinase activity, protein serine/threonine kinase activity, RNA binding...
ATP binding, magnesium ion binding, MAP kinase kinase kinase activity, protein serine/threonine kinase activity, RNA binding
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GO - Cellular component (CC):
cytosol, nucleus, cytoplasm...
cytosol, nucleus, cytoplasm
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mitogen-activated protein kinase kinase kinase 20
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Kaplan plot for MAP3K20 in
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*NOTE: the Kaplan plots were collected from OncoLnc