CDK12
Entrez ID: 51755
Full name: cyclin dependent kinase 12
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: CDK: CRK7
Chromosomal location: 17q12
Substructure location: Gatekeeper: 813 A-loop: 876...888, 890...900 G-loop: 733...739 αC-helix: 769...778
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CDK12
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability...
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
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GO - Biological processes (BP):
mRNA processing, negative regulation of stem cell differentiation, phosphorylation of RNA polymerase II C-terminal domain, positive regulation of transcription elongation from RNA polymerase II promoter, protein autophosphorylation, protein phosphorylation, regulation of MAP kinase activity, regulat...
mRNA processing, negative regulation of stem cell differentiation, phosphorylation of RNA polymerase II C-terminal domain, positive regulation of transcription elongation from RNA polymerase II promoter, protein autophosphorylation, protein phosphorylation, regulation of MAP kinase activity, regulation of RNA splicing, RNA splicing
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GO - Molecular function (MF):
ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, protein kinase activity, protein kinase binding, RNA polymerase II CTD heptapeptide repeat kinase activity...
ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, protein kinase activity, protein kinase binding, RNA polymerase II CTD heptapeptide repeat kinase activity
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GO - Cellular component (CC):
nuclear chromatin, nuclear cyclin-dependent protein kinase holoenzyme complex, nuclear speck, nucleoplasm, nucleus, cyclin K-CDK12 complex, cyclin-dependent protein kinase holoenzyme complex...
nuclear chromatin, nuclear cyclin-dependent protein kinase holoenzyme complex, nuclear speck, nucleoplasm, nucleus, cyclin K-CDK12 complex, cyclin-dependent protein kinase holoenzyme complex
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cyclin dependent kinase 12
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*NOTE: the Kaplan plots were collected from OncoLnc