MARK1
Entrez ID: 4139
Full name: microtubule affinity regulating kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: CAMKL: MARK
Chromosomal location: 1q41
Substructure location: Gatekeeper: 136 A-loop: 199...221 G-loop: 66...72 αC-helix: 98...113
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MARK1
Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated p...
Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
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GO - Biological processes (BP):
cytoskeleton organization, establishment of mitochondrion localization, intracellular signal transduction, microtubule cytoskeleton organization, neuron migration, peptidyl-serine phosphorylation, protein phosphorylation, regulation of dendrite development, regulation of neuron projection developmen...
cytoskeleton organization, establishment of mitochondrion localization, intracellular signal transduction, microtubule cytoskeleton organization, neuron migration, peptidyl-serine phosphorylation, protein phosphorylation, regulation of dendrite development, regulation of neuron projection development, Wnt signaling pathway
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GO - Molecular function (MF):
ATP binding, magnesium ion binding, phosphatidic acid binding, phosphatidylinositol-4,5-bisphosphate binding, phosphatidylserine binding, protein serine/threonine kinase activity, tau protein binding, tau-protein kinase activity...
ATP binding, magnesium ion binding, phosphatidic acid binding, phosphatidylinositol-4,5-bisphosphate binding, phosphatidylserine binding, protein serine/threonine kinase activity, tau protein binding, tau-protein kinase activity
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GO - Cellular component (CC):
cytoskeleton, microtubule cytoskeleton, plasma membrane, cytoplasm, dendrite...
cytoskeleton, microtubule cytoskeleton, plasma membrane, cytoplasm, dendrite
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microtubule affinity regulating kinase 1
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*NOTE: the Kaplan plots were collected from OncoLnc