PIM2
Entrez ID: 11040
Full name: Pim-2 proto-oncogene, serine/threonine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: PIM
Chromosomal location: Xp11.23
Substructure location: Gatekeeper: 116 A-loop: 181...202 G-loop: 37...47 αC-helix: 82...91
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PIM2
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through surv...
Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.
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GO - Biological processes (BP):
apoptotic mitochondrial changes, G1/S transition of mitotic cell cycle, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of protein binding, positive regulation of autophagy, positive regulation of I-kappaB kinase/NF-kappaB signaling...
apoptotic mitochondrial changes, G1/S transition of mitotic cell cycle, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of protein binding, positive regulation of autophagy, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of macroautophagy, positive regulation of transcription, DNA-templated, protein autophosphorylation, protein phosphorylation, protein stabilization, regulation of mitotic cell cycle, response to virus
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GO - Molecular function (MF):
ATP binding, protein serine/threonine kinase activity...
ATP binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytoplasm...
cytoplasm
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Pim-2 proto-oncogene, serine/threonine kinase
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*NOTE: the Kaplan plots were collected from OncoLnc