PAK5
Entrez ID: 57144
Full name: p21 (RAC1) activated kinase 5
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: PAKB
Chromosomal location: 20p12.2
Substructure location: Gatekeeper: 523 A-loop: 585...608 G-loop: 455...461 αC-helix: 482...484
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PAK5
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational cha...
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
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GO - Biological processes (BP):
activation of protein kinase activity, apoptotic process, cell migration, cell population proliferation, cytoskeleton organization, learning, locomotory behavior, memory, negative regulation of extrinsic apoptotic signaling pathway, regulation of cell growth, regulation of mitotic cell cycle, signal...
activation of protein kinase activity, apoptotic process, cell migration, cell population proliferation, cytoskeleton organization, learning, locomotory behavior, memory, negative regulation of extrinsic apoptotic signaling pathway, regulation of cell growth, regulation of mitotic cell cycle, signal transduction, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, protein serine/threonine kinase activity...
ATP binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
mitochondrion, nucleoplasm, cytoplasm, synapse...
mitochondrion, nucleoplasm, cytoplasm, synapse
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p21 (RAC1) activated kinase 5
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Kaplan plot for PAK5 in
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*NOTE: the Kaplan plots were collected from OncoLnc