STK39
Entrez ID: 27347
Full name: serine/threonine kinase 39
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: FRAY
Chromosomal location: 2q24.3
Substructure location: Gatekeeper: 138 A-loop: 209...222, 229...237 G-loop: [N/A] αC-helix: [N/A]
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STK39
May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT....
May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT.
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GO - Biological processes (BP):
activation of MAPK activity, activation of protein kinase activity, cellular hypotonic response, cellular response to chemokine, chemokine (C-X-C motif) ligand 12 signaling pathway, intracellular signal transduction, ion homeostasis, maintenance of lens transparency, negative regulation of creatine ...
activation of MAPK activity, activation of protein kinase activity, cellular hypotonic response, cellular response to chemokine, chemokine (C-X-C motif) ligand 12 signaling pathway, intracellular signal transduction, ion homeostasis, maintenance of lens transparency, negative regulation of creatine transmembrane transporter activity, negative regulation of pancreatic juice secretion, negative regulation of potassium ion transmembrane transport, negative regulation of potassium ion transmembrane transporter activity, negative regulation of sodium ion transmembrane transporter activity, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of ion transmembrane transporter activity, positive regulation of potassium ion transport, positive regulation of T cell chemotaxis, protein autophosphorylation, protein phosphorylation, regulation of blood pressure, regulation of inflammatory response, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, signal transduction by trans-phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, kinase activity, protein kinase binding, protein serine/threonine kinase activity...
ATP binding, kinase activity, protein kinase binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytoskeleton, cytosol, nucleoplasm, apical plasma membrane, basolateral plasma membrane, cytoplasm, extrinsic component of membrane, intracellular membrane-bounded organelle...
cytoskeleton, cytosol, nucleoplasm, apical plasma membrane, basolateral plasma membrane, cytoplasm, extrinsic component of membrane, intracellular membrane-bounded organelle
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serine/threonine kinase 39
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Kaplan plot for STK39 in
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*NOTE: the Kaplan plots were collected from OncoLnc