EPHA6
Entrez ID: 285220
Full name: EPH receptor A6
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Eph
Chromosomal location: 3q11.2
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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EPHA6
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pa...
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).
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GO - Biological processes (BP):
axon guidance, ephrin receptor signaling pathway, multicellular organism development, positive regulation of kinase activity, transmembrane receptor protein tyrosine kinase signaling pathway...
axon guidance, ephrin receptor signaling pathway, multicellular organism development, positive regulation of kinase activity, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, transmembrane-ephrin receptor activity, transmembrane receptor protein tyrosine kinase activity...
ATP binding, transmembrane-ephrin receptor activity, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
nucleoplasm, integral component of plasma membrane, plasma membrane, neuron projection, receptor complex...
nucleoplasm, integral component of plasma membrane, plasma membrane, neuron projection, receptor complex
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EPH receptor A6
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 5 samples
Minimum 10 samples
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Kaplan plot for EPHA6 in
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*NOTE: the Kaplan plots were collected from OncoLnc