RPS6KA6
Entrez ID: 27330
Full name: ribosomal protein S6 kinase A6
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: RSK: RSKp90
Chromosomal location: Xq21.1
Substructure location: Gatekeeper: 152 A-loop: 215...226, 228...238, 564...587 G-loop: [N/A] αC-helix: [N/A]
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RPS6KA6
Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis....
Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis.
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GO - Biological processes (BP):
central nervous system development, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, intracellular signal transduction, negative regulation of embryonic development, negative regulation of ERK1 and ERK2 cascade, negative regulation of m...
central nervous system development, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, intracellular signal transduction, negative regulation of embryonic development, negative regulation of ERK1 and ERK2 cascade, negative regulation of mesoderm development, protein phosphorylation, signal transduction
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GO - Molecular function (MF):
ATP binding, magnesium ion binding, protein kinase activity, protein serine/threonine kinase activity, ribosomal protein S6 kinase activity...
ATP binding, magnesium ion binding, protein kinase activity, protein serine/threonine kinase activity, ribosomal protein S6 kinase activity
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GO - Cellular component (CC):
cytosol, mitochondrion, fibrillar center, nucleolus, nucleoplasm, nucleus, cytoplasm...
cytosol, mitochondrion, fibrillar center, nucleolus, nucleoplasm, nucleus, cytoplasm
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ribosomal protein S6 kinase A6
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Kaplan plot for RPS6KA6 in
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*NOTE: the Kaplan plots were collected from OncoLnc