TLK1
Entrez ID: 9874
Full name: tousled like kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: TLK
Chromosomal location: 2q31.1
Substructure location: Gatekeeper: 538 A-loop: 606...635 G-loop: [N/A] αC-helix: [N/A]
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TLK1
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of...
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
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GO - Biological processes (BP):
cell cycle, cellular response to DNA damage stimulus, chromatin organization, chromosome segregation, intracellular protein transport, intracellular signal transduction, peptidyl-serine phosphorylation, protein phosphorylation, regulation of chromatin assembly or disassembly...
cell cycle, cellular response to DNA damage stimulus, chromatin organization, chromosome segregation, intracellular protein transport, intracellular signal transduction, peptidyl-serine phosphorylation, protein phosphorylation, regulation of chromatin assembly or disassembly
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GO - Molecular function (MF):
ATP binding, protein serine/threonine kinase activity...
ATP binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
nucleoplasm, nucleus...
nucleoplasm, nucleus
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tousled like kinase 1
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Kaplan plot for TLK1 in
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*NOTE: the Kaplan plots were collected from OncoLnc