TAOK2
Entrez ID: 9344
Full name: TAO kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: TAO
Chromosomal location: 16p11.2
Substructure location: Gatekeeper: 105 A-loop: 168...187 G-loop: [N/A] αC-helix: [N/A]
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TAOK2
Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK sign...
Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation.
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GO - Biological processes (BP):
actin cytoskeleton organization, activation of JUN kinase activity, activation of MAPK activity, activation of MAPKK activity, activation of protein kinase activity, apoptotic process, axonogenesis, basal dendrite arborization, basal dendrite morphogenesis, cell migration, cellular response to DNA d...
actin cytoskeleton organization, activation of JUN kinase activity, activation of MAPK activity, activation of MAPKK activity, activation of protein kinase activity, apoptotic process, axonogenesis, basal dendrite arborization, basal dendrite morphogenesis, cell migration, cellular response to DNA damage stimulus, focal adhesion assembly, mitotic G2 DNA damage checkpoint, positive regulation of JNK cascade, positive regulation of protein autophosphorylation, positive regulation of stress-activated MAPK cascade, protein autophosphorylation, protein targeting to membrane, regulation of actin cytoskeleton organization, regulation of cell growth, regulation of cell shape, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated MAPK cascade, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, MAP kinase kinase kinase activity, mitogen-activated protein kinase kinase binding, neuropilin binding, protein serine/threonine kinase activity, tau protein binding, tau-protein kinase activity...
ATP binding, MAP kinase kinase kinase activity, mitogen-activated protein kinase kinase binding, neuropilin binding, protein serine/threonine kinase activity, tau protein binding, tau-protein kinase activity
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GO - Cellular component (CC):
actin cytoskeleton, cytosol, nucleolus, nucleoplasm, axon, axonal growth cone, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, dendritic growth cone, integral component of membrane, neuron projection, receptor complex...
actin cytoskeleton, cytosol, nucleolus, nucleoplasm, axon, axonal growth cone, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, dendritic growth cone, integral component of membrane, neuron projection, receptor complex
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TAO kinase 2
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Kaplan plot for TAOK2 in
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*NOTE: the Kaplan plots were collected from OncoLnc