ALK
Entrez ID: 238
Full name: ALK receptor tyrosine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: ALK
Chromosomal location: 2p23.2-p23.1
Substructure location: Gatekeeper: 1196 A-loop: 1269...1294 G-loop: 1122...1128 αC-helix: 1158...1173
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ALK
Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specifi...
Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.
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GO - Biological processes (BP):
activation of MAPK activity, adult behavior, hippocampus development, multicellular organism development, neuron development, phosphorylation, positive regulation of dendrite development, positive regulation of kinase activity, positive regulation of NF-kappaB transcription factor activity, protein ...
activation of MAPK activity, adult behavior, hippocampus development, multicellular organism development, neuron development, phosphorylation, positive regulation of dendrite development, positive regulation of kinase activity, positive regulation of NF-kappaB transcription factor activity, protein autophosphorylation, regulation of apoptotic process, regulation of cell population proliferation, regulation of dopamine receptor signaling pathway, regulation of neuron differentiation, response to environmental enrichment, signal transduction, swimming behavior, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, identical protein binding, NF-kappaB-inducing kinase activity, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity...
ATP binding, identical protein binding, NF-kappaB-inducing kinase activity, protein tyrosine kinase activity, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
extracellular exosome, integral component of plasma membrane, plasma membrane, protein-containing complex, receptor complex...
extracellular exosome, integral component of plasma membrane, plasma membrane, protein-containing complex, receptor complex
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ALK receptor tyrosine kinase
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Kaplan plot for ALK in
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*NOTE: the Kaplan plots were collected from OncoLnc