TRIM33
Entrez ID: 51592
Full name: tripartite motif containing 33
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: TIF1
Chromosomal location: 1p13.2
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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TRIM33
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptio...
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
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GO - Biological processes (BP):
negative regulation of BMP signaling pathway, negative regulation of transcription, DNA-templated, negative regulation of transcription by RNA polymerase II, protein ubiquitination, regulation of transforming growth factor beta receptor signaling pathway...
negative regulation of BMP signaling pathway, negative regulation of transcription, DNA-templated, negative regulation of transcription by RNA polymerase II, protein ubiquitination, regulation of transforming growth factor beta receptor signaling pathway
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GO - Molecular function (MF):
co-SMAD binding, DNA binding, R-SMAD binding, ubiquitin-protein transferase activity, zinc ion binding...
co-SMAD binding, DNA binding, R-SMAD binding, ubiquitin-protein transferase activity, zinc ion binding
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GO - Cellular component (CC):
nucleoplasm, nucleus...
nucleoplasm, nucleus
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tripartite motif containing 33
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*NOTE: the Kaplan plots were collected from OncoLnc