CILK1
Entrez ID: 22858
Full name: ciliogenesis associated kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: RCK: MAK
Chromosomal location: 6p12.1
Substructure location: Gatekeeper: 79 A-loop: 142...152, 155...164 G-loop: [N/A] αC-helix: [N/A]
Please click HERE
for better display.
CILK1
Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key r...
Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity).
View more >>
GO - Biological processes (BP):
cilium assembly, intracellular signal transduction, intraciliary anterograde transport, intraciliary retrograde transport, intraciliary transport, multicellular organism development, protein phosphorylation, regulation of gene expression, signal transduction...
cilium assembly, intracellular signal transduction, intraciliary anterograde transport, intraciliary retrograde transport, intraciliary transport, multicellular organism development, protein phosphorylation, regulation of gene expression, signal transduction
View more >>
GO - Molecular function (MF):
ATP binding, magnesium ion binding, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, magnesium ion binding, protein kinase activity, protein serine/threonine kinase activity
View more >>
GO - Cellular component (CC):
ciliary basal body, cytosol, fibrillar center, nucleus, ciliary base, ciliary tip, cilium, cytoplasm...
ciliary basal body, cytosol, fibrillar center, nucleus, ciliary base, ciliary tip, cilium, cytoplasm
View more >>
ciliogenesis associated kinase 1
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for CILK1 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc