AURKC
Entrez ID: 6795
Full name: aurora kinase C
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: Aur
Chromosomal location: 19q13.43
Substructure location: Gatekeeper: 120 A-loop: 183...204 G-loop: [N/A] αC-helix: [N/A]
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AURKC
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubul...
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
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GO - Biological processes (BP):
attachment of spindle microtubules to kinetochore, cell division, histone modification, meiotic cell cycle, mitotic spindle midzone assembly, mitotic spindle organization, oocyte development, positive regulation of cytokinesis, protein phosphorylation, regulation of cytokinesis, spermatogenesis...
attachment of spindle microtubules to kinetochore, cell division, histone modification, meiotic cell cycle, mitotic spindle midzone assembly, mitotic spindle organization, oocyte development, positive regulation of cytokinesis, protein phosphorylation, regulation of cytokinesis, spermatogenesis
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GO - Molecular function (MF):
ATP binding, histone serine kinase activity, protein kinase activity, protein serine/threonine/tyrosine kinase activity...
ATP binding, histone serine kinase activity, protein kinase activity, protein serine/threonine/tyrosine kinase activity
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GO - Cellular component (CC):
chromosome passenger complex, spindle, spindle microtubule, spindle midzone, spindle pole centrosome, condensed nuclear chromosome, centromeric region, condensed chromosome, cytoplasm, midbody...
chromosome passenger complex, spindle, spindle microtubule, spindle midzone, spindle pole centrosome, condensed nuclear chromosome, centromeric region, condensed chromosome, cytoplasm, midbody
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aurora kinase C
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Kaplan plot for AURKC in
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*NOTE: the Kaplan plots were collected from OncoLnc