CAMK2A
Entrez ID: 815
Full name: calcium/calmodulin dependent protein kinase II alpha
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: CAMK2
Chromosomal location: 5q32
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: [N/A] αC-helix: 33...35
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CAMK2A
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR...
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378).
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GO - Biological processes (BP):
angiotensin-activated signaling pathway, calcium ion transport, dendritic spine development, G1/S transition of mitotic cell cycle, interferon-gamma-mediated signaling pathway, peptidyl-serine phosphorylation, peptidyl-threonine autophosphorylation, positive regulation of calcium ion transport, posi...
angiotensin-activated signaling pathway, calcium ion transport, dendritic spine development, G1/S transition of mitotic cell cycle, interferon-gamma-mediated signaling pathway, peptidyl-serine phosphorylation, peptidyl-threonine autophosphorylation, positive regulation of calcium ion transport, positive regulation of cardiac muscle cell apoptotic process, positive regulation of NF-kappaB transcription factor activity, protein autophosphorylation, protein phosphorylation, regulation of cellular response to heat, regulation of mitochondrial membrane permeability involved in apoptotic process, regulation of neuronal synaptic plasticity, regulation of neuron migration, regulation of neurotransmitter secretion, response to ischemia, Wnt signaling pathway, calcium modulating pathway
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GO - Molecular function (MF):
ATP binding, calcium-dependent protein serine/threonine kinase activity, calmodulin binding, calmodulin-dependent protein kinase activity, glutamate receptor binding, identical protein binding, kinase activity, metal ion binding, protein homodimerization activity, protein serine/threonine kinase act...
ATP binding, calcium-dependent protein serine/threonine kinase activity, calmodulin binding, calmodulin-dependent protein kinase activity, glutamate receptor binding, identical protein binding, kinase activity, metal ion binding, protein homodimerization activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, mitochondrion, nucleoplasm, nucleus, calcium- and calmodulin-dependent protein kinase complex, cell junction, cytoplasm, dendritic spine, endocytic vesicle membrane, neuron projection, postsynaptic density...
cytosol, mitochondrion, nucleoplasm, nucleus, calcium- and calmodulin-dependent protein kinase complex, cell junction, cytoplasm, dendritic spine, endocytic vesicle membrane, neuron projection, postsynaptic density
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calcium/calmodulin dependent protein kinase II alpha
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Kaplan plot for CAMK2A in
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*NOTE: the Kaplan plots were collected from OncoLnc