AKT3
Entrez ID: 10000
Full name: AKT serine/threonine kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: Akt
Chromosomal location: 1q43-q44
Substructure location: Gatekeeper: 225 A-loop: 288...311 G-loop: [N/A] αC-helix: [N/A]
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AKT3
AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of...
AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
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GO - Biological processes (BP):
intracellular signal transduction, mitochondrial genome maintenance, negative regulation of cellular senescence, peptidyl-serine phosphorylation, positive regulation of blood vessel endothelial cell migration, positive regulation of cell migration involved in sprouting angiogenesis, positive regulat...
intracellular signal transduction, mitochondrial genome maintenance, negative regulation of cellular senescence, peptidyl-serine phosphorylation, positive regulation of blood vessel endothelial cell migration, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of endothelial cell proliferation, positive regulation of vascular endothelial cell proliferation, protein phosphorylation, signal transduction
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GO - Molecular function (MF):
ATP binding, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
nucleus, cytoplasm, membrane...
nucleus, cytoplasm, membrane
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AKT serine/threonine kinase 3
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*NOTE: the Kaplan plots were collected from OncoLnc