SIK3
Entrez ID: 23387
Full name: SIK family kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: CAMKL: QIK
Chromosomal location: 11q23.3
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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SIK3
Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting ...
Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity).
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GO - Biological processes (BP):
intracellular signal transduction, microtubule cytoskeleton organization, positive regulation of TORC1 signaling, positive regulation of TORC2 signaling, protein phosphorylation...
intracellular signal transduction, microtubule cytoskeleton organization, positive regulation of TORC1 signaling, positive regulation of TORC2 signaling, protein phosphorylation
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GO - Molecular function (MF):
ATP binding, magnesium ion binding, protein serine/threonine kinase activity, tau-protein kinase activity...
ATP binding, magnesium ion binding, protein serine/threonine kinase activity, tau-protein kinase activity
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GO - Cellular component (CC):
cytoplasm...
cytoplasm
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SIK family kinase 3
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 5 samples
Minimum 10 samples
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Kaplan plot for SIK3 in
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*NOTE: the Kaplan plots were collected from OncoLnc