MAP3K2
Entrez ID: 10746
Full name: mitogen-activated protein kinase kinase kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE11: MEKK2
Chromosomal location: 2q14.3
Substructure location: Gatekeeper: [N/A] A-loop: 500...526 G-loop: [N/A] αC-helix: [N/A]
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MAP3K2
Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics....
Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.
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GO - Biological processes (BP):
activation of JUN kinase activity, activation of MAPK activity, activation of protein kinase activity, cellular response to mechanical stimulus, positive regulation of transcription, DNA-templated, protein phosphorylation, regulation of mitotic cell cycle, signal transduction by protein phosphorylat...
activation of JUN kinase activity, activation of MAPK activity, activation of protein kinase activity, cellular response to mechanical stimulus, positive regulation of transcription, DNA-templated, protein phosphorylation, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, MAP kinase kinase kinase activity, metal ion binding, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity...
ATP binding, MAP kinase kinase kinase activity, metal ion binding, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, nucleoplasm, cytoplasm...
cytosol, nucleoplasm, cytoplasm
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mitogen-activated protein kinase kinase kinase 2
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*NOTE: the Kaplan plots were collected from OncoLnc