DYRK1B
Entrez ID: 9149
Full name: dual specificity tyrosine phosphorylation regulated kinase 1B
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: DYRK: DYRK1
Chromosomal location: 19q13.2
Substructure location: Gatekeeper: 190 A-loop: 258...278 G-loop: [N/A] αC-helix: [N/A]
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DYRK1B
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, th...
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC).
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GO - Biological processes (BP):
adipose tissue development, myoblast fusion, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of transcription, DNA-templated, protein autophosphorylation, protein phosphorylation...
adipose tissue development, myoblast fusion, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of transcription, DNA-templated, protein autophosphorylation, protein phosphorylation
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GO - Molecular function (MF):
ATP binding, protein kinase activity, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transcription coactivator activity...
ATP binding, protein kinase activity, protein serine/threonine/tyrosine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transcription coactivator activity
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GO - Cellular component (CC):
nucleoplasm, nucleus...
nucleoplasm, nucleus
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dual specificity tyrosine phosphorylation regulated kinase 1B
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Kaplan plot for DYRK1B in
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*NOTE: the Kaplan plots were collected from OncoLnc