CDC42BPB
Entrez ID: 9578
Full name: CDC42 binding protein kinase beta
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: DMPK: GEK
Chromosomal location: 14q32.32
Substructure location: Gatekeeper: 153 A-loop: 217...241 G-loop: 81...88 αC-helix: [N/A]
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CDC42BPB
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In co...
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity).
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GO - Biological processes (BP):
actin cytoskeleton reorganization, actomyosin structure organization, cell migration, cytoskeleton organization, establishment or maintenance of cell polarity, intracellular signal transduction, peptidyl-threonine phosphorylation, protein phosphorylation, signal transduction...
actin cytoskeleton reorganization, actomyosin structure organization, cell migration, cytoskeleton organization, establishment or maintenance of cell polarity, intracellular signal transduction, peptidyl-threonine phosphorylation, protein phosphorylation, signal transduction
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GO - Molecular function (MF):
ATP binding, magnesium ion binding, protein-containing complex binding, protein kinase activity, protein serine/threonine kinase activity, Rho GTPase binding...
ATP binding, magnesium ion binding, protein-containing complex binding, protein kinase activity, protein serine/threonine kinase activity, Rho GTPase binding
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GO - Cellular component (CC):
actomyosin, cytoskeleton, extracellular exosome, plasma membrane, cell leading edge, cell-cell junction, cytoplasm, lamellipodium...
actomyosin, cytoskeleton, extracellular exosome, plasma membrane, cell leading edge, cell-cell junction, cytoplasm, lamellipodium
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CDC42 binding protein kinase beta
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Kaplan plot for CDC42BPB in
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*NOTE: the Kaplan plots were collected from OncoLnc